Xenografting of adult mammalian testis tissue
نویسندگان
چکیده
منابع مشابه
Xenografting of adult mammalian testis tissue.
Xenografting of testis tissue from immature males from several mammalian species to immunodeficient mouse hosts results in production of fertilization-competent sperm. However, the efficiency of testis tissue xenografting from adult donors has not been critically evaluated. Testis tissue xenografting from sexually mature animals could provide an option to preserve the genetic material from valu...
متن کاملRecent developments in testis tissue xenografting.
Development of the mammalian testis and spermatogenesis involve complex processes of cell migration, proliferation, differentiation, and cell-cell interactions. Although our knowledge of these processes has increased in the last few decades, many aspects still remain unclear. The lack of suitable systems that allow to recapitulate and manipulate both testis development and spermatogenesis ex si...
متن کاملXenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation
BACKGROUND Abnormal fetal testis development can result in disorders of sex development (DSDs) and predispose to later testicular dysgenesis syndrome (TDS) disorders such as testicular germ cell tumours. Studies of human fetal testis development are hampered by the lack of appropriate model, and intervention systems. We hypothesized that human fetal testis xenografts can recapitulate normal dev...
متن کاملThe Number of Grafted Fragments Affects the Outcome of Testis Tissue Xenografting from Piglets into Recipient Mice
To optimize the procedure for testis tissue xenografting, we grafted 2, 4, 8, or 16 small fragments of immature porcine testis tissue under the back skin of immunodeficient castrated mice (n = 10 mice/group). At 8 months post grafting, the graft recovery rate did not differ between groups; however, not only the total but also the average graft weights were higher (by approximately 12-fold and a...
متن کاملGene expression in human ovarian tissue after xenografting.
Cryobanking and transplantation of ovarian tissue is a promising approach to restore fertility in cancer patients. However, ischemic stress following avascular ovarian cortex grafting is known to induce stromal tissue fibrosis and alterations in follicular development. The aim of the study was to analyze the impact of freeze-thawing and grafting procedures on gene expression in human ovarian ti...
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ژورنال
عنوان ژورنال: Animal Reproduction Science
سال: 2008
ISSN: 0378-4320
DOI: 10.1016/j.anireprosci.2007.03.026